Purpose: Fibrosis, characterized by the accumulation of collagen, is a late result of thoracic
irradiation. The expression of late radiation injury can be found immediately after irradiation …

Purpose: To examine and compare the molecular and cellular processes leading to
radiation fibrosis and pneumonitis in C57BL/6J and C3H/HeN mice. Methods and Materials …

Macrophages display different phenotypes that can switch in response to their micro-
environment. In our earlier study (Chiang, CS, Liu, WC and Jung, SM, 2005. Compartmental …

Purpose: Radiation-induced pulmonary reactions have classically been viewed as distinct
phases-acute pneumonitis and, later, fibrosis-occurring at different times after irradiation and …

Fibrosis of lung tissue is a frequent and serious consequence of radiotherapy of mammary
carcinoma. The pathogenesis of radiation-induced pulmonary fibrosis remains unclear …

Purpose: Thoracic irradiation injures lung parenchyma, triggering inflammation and immune
cell activation, leading to pneumonitis and fibrosis. Macrophage polarization contributes to …

There is a great deal of evidence that a cyclic cascade of inflammatory cytokines, together
with the activation of macrophages, is initiated very early after irradiation to develop lung …

The mechanisms leading to the radiation-induced lung responses of alveolitis and fibrosis
are largely unknown. Herein we investigated whether CXC receptor 1 and 2 antagonism …

The chemokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are
neutrophil and monocyte attractants, respectively. We hypothesized that IL-8 and MCP-1 …

Therapeutic thoracic irradiation may induce two late pulmonary injury syndromes: radiation
pneumonitis and subsequent pulmonary fibrosis. The alveolar macrophage has been …