Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis
JN Finkelstein, CJ Johnston, R Baggs… - International Journal of …, 1994 - Elsevier
Purpose: Fibrosis, characterized by the accumulation of collagen, is a late result of thoracic
irradiation. The expression of late radiation injury can be found immediately after irradiation …
irradiation. The expression of late radiation injury can be found immediately after irradiation …
Compartmental responses after thoracic irradiation of mice: strain differences
CS Chiang, WC Liu, SM Jung, FH Chen, CR Wu… - International Journal of …, 2005 - Elsevier
Purpose: To examine and compare the molecular and cellular processes leading to
radiation fibrosis and pneumonitis in C57BL/6J and C3H/HeN mice. Methods and Materials …
radiation fibrosis and pneumonitis in C57BL/6J and C3H/HeN mice. Methods and Materials …
Functional phenotype of macrophages depends on assay procedures
CS Chiang, FH Chen, JH Hong, PS Jiang… - International …, 2008 - academic.oup.com
Macrophages display different phenotypes that can switch in response to their micro-
environment. In our earlier study (Chiang, CS, Liu, WC and Jung, SM, 2005. Compartmental …
environment. In our earlier study (Chiang, CS, Liu, WC and Jung, SM, 2005. Compartmental …
A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis
P Rubin, CJ Johnston, JP Williams, S McDonald… - International Journal of …, 1995 - Elsevier
Purpose: Radiation-induced pulmonary reactions have classically been viewed as distinct
phases-acute pneumonitis and, later, fibrosis-occurring at different times after irradiation and …
phases-acute pneumonitis and, later, fibrosis-occurring at different times after irradiation and …
Local production of interleukin-4 during radiation-induced pneumonitis and pulmonary fibrosis in rats: macrophages as a prominent source of interleukin-4
C Buttner, A Skupin, T Reimann, EP Rieber… - American journal of …, 1997 - atsjournals.org
Fibrosis of lung tissue is a frequent and serious consequence of radiotherapy of mammary
carcinoma. The pathogenesis of radiation-induced pulmonary fibrosis remains unclear …
carcinoma. The pathogenesis of radiation-induced pulmonary fibrosis remains unclear …
Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation
AM Groves, CJ Johnston, RS Misra… - … Journal of Radiation …, 2016 - Taylor & Francis
Purpose: Thoracic irradiation injures lung parenchyma, triggering inflammation and immune
cell activation, leading to pneumonitis and fibrosis. Macrophage polarization contributes to …
cell activation, leading to pneumonitis and fibrosis. Macrophage polarization contributes to …
Attenuated lung fibrosis in interleukin 6 knock-out mice after C-ion irradiation to lung
T Saito-Fujita, M Iwakawa, E Nakamura… - Journal of radiation …, 2011 - jstage.jst.go.jp
There is a great deal of evidence that a cyclic cascade of inflammatory cytokines, together
with the activation of macrophages, is initiated very early after irradiation to develop lung …
with the activation of macrophages, is initiated very early after irradiation to develop lung …
Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse
J Fox, JR Gordon, CK Haston - Radiation Research, 2011 - meridian.allenpress.com
The mechanisms leading to the radiation-induced lung responses of alveolitis and fibrosis
are largely unknown. Herein we investigated whether CXC receptor 1 and 2 antagonism …
are largely unknown. Herein we investigated whether CXC receptor 1 and 2 antagonism …
Interleukin-8 and monocyte chemoattractant protein-1 mRNAs in oxygen-injured rabbit lung
CT D'angio, RA Sinkin… - American Journal of …, 1995 - journals.physiology.org
The chemokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are
neutrophil and monocyte attractants, respectively. We hypothesized that IL-8 and MCP-1 …
neutrophil and monocyte attractants, respectively. We hypothesized that IL-8 and MCP-1 …
Release of interleukin-1 by human alveolar macrophages after in vitro irradiation
A O'Brien-Ladner, ME Nelson, BF Kimler… - Radiation …, 1993 - meridian.allenpress.com
Therapeutic thoracic irradiation may induce two late pulmonary injury syndromes: radiation
pneumonitis and subsequent pulmonary fibrosis. The alveolar macrophage has been …
pneumonitis and subsequent pulmonary fibrosis. The alveolar macrophage has been …