Influenza virus infections induce chemokines and cytokines, which regulate the immune
response. The chemokine receptor CCR2 plays an important role in macrophage …

Purpose: Radiation-induced pneumonitis and subsequent pulmonary fibrosis are important
dose-limiting complications of radiotherapy. Their pathogenesis is known onlyin part. T …

Radiation pneumonitis remains a critical dose-limiting toxicity of total body irradiation (TBI)
for use in bone marrow transplantation. The acute and chronic phases of radiation damage …

Ionizing irradiation damage to the lung is associated with an acute inflammatory reaction,
followed by a latent period and then late effects including predominantly pulmonary fibrosis …

Interleukin-4 (IL-4) is known to activate mononuclear cells as well as fibroblasts, all of which
are important in the pathogenesis of pulmonary fibrosis. To investigate the potential role of …

The mechanisms responsible for the induction of matrix-degrading proteases during lung
injury are ill defined. Macrophage-derived mediators are believed to play a role in regulating …

Inhaled endotoxin (lipopolysaccharide, LPS) can induce acute lung injury and at high doses
may lead to respiratory distress syndrome. Using a mouse model of acute lung inflammation …

Materials and Methods Animal Model Pulmonary fibrosis was induced in adult male
pathogen-free Fisher rats (175to 224 g)(Charles River, Portage, MI) by intratracheal injection …

Levels of pulmonary and activation-regulated chemokine (PARC) mRNA and protein are
increased in the lungs of patients with pulmonary fibrosis. The purpose of this study was to …

Systemic exposure to LPS initiates a complex sequence of events culminating in organ-
specific leukocyte recruitment and end organ injury. We hypothesized that RANTES, a CC …