Background: Hepatic encephalopathy is considered to be mainly caused by increased
ammonia metabolism of the brain. If this hypothesis is true, cerebral glucose utilisation …

Clinical and histopathological findings hint at regional differences in the brain's sensitivity to
metabolic changes in cirrhosis. The aim of the present study was to examine regional …

Brain imaging techniques have provided substantial insight into the pathophysiology of
hepatic encephalopathy (HE). Magnetic resonance imaging gave hint to the fact that there is …

BACKGROUND & AIMS: It is unclear whether patients with hepatic encephalopathy (HE)
have disturbed brain oxygen metabolism and blood flow. METHODS: We measured cerebral …

Chronic hepatic encephalopathy is a characteristically reversible neuropsychiatric disorder
that occurs mainly in patients with liver cirrhosis. The brain regions critically involved in the …

Animal studies and results from 13N‐ammonia positron emission tomography (PET) in
patients with cirrhosis and minimal hepatic encephalopathy suggest that a disturbed brain …

Background/Aims: Liver failure may cause brain edema through an increase in brain
glutamine. However, usually standard neuroimaging techniques do not detect brain edema …

Studies have shown decreased cerebral oxygen metabolism (CMRO2) and blood flow
(CBF) in patients with cirrhosis with hepatic encephalopathy (HE). It remains unclear …

Aim To examine whether the brain exhibits metabolic disorder prior to overt hepatic
encephalopathy in patients with liver cirrhosis (LC), the intracerebral glutamine and myo …

Results of neuropathologic, spectroscopic, and neurochemical studies continue to confirm a
major role for ammonia in the pathogenesis of the central nervous system complications of …