Pathogenic Gram-positive bacteria encounter many obstacles in route to successful invasion
and subversion of a mammalian host. As such, bacterial species have evolved clever ways …

Cell-wall sorted proteins of the Staphylococcus aureus iron-regulated surface determinant
system bind human hemoproteins, remove the heme molecule, and transport heme through …

Staphylococcus aureus is a human pathogen that represents a tremendous threat to global
public health. An important aspect of S. aureus pathogenicity is the ability to acquire iron …

The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus
aureus has been previously shown to be reliant on the acquisition of iron from host …

The unique redox potential of iron makes it an ideal cofactor in diverse biochemical
reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms …

The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently
most living organisms, including pathogenic bacteria, require iron to survive and replicate …

The bacterium Staphylococcus aureus is responsible for numerous hospital-acquired
infections ranging from superficial wound lesions to more severe infections such as …

In this study, we report experimental results that provide the first complete challenge of a
proposed model for heme acquisition by Staphylococcus aureus via the Isd pathway first put …

Most of the iron in a mammalian body is complexed with various proteins. Moreover, in
response to infection, iron availability is reduced in both extracellular and intracellular …

The iron-regulated surface determinants (Isd) of Staphylococcus aureus, including surface
proteins IsdA, IsdB, IsdC, and IsdH and ATP-binding cassette transporter IsdDEF, constitute …