The ability of microorganisms that would like to live in or on mammalian hosts to acquire iron
is a critical determinant of the host-parasite interaction. Despite the abundance of iron, its …

Pseudomonas aeruginosa is an opportunistic pathogen able to infect any human tissue.
One of the reasons for its high adaptability and colonization of host tissues is its capacity of …

Despite the ability of staphylococci to grow in iron-restricted conditions in vivo, their iron
requirements and the mechanisms possessed by them for the uptake of iron are poorly …

Numerous bacterial proteins are involved in microbial iron uptake and transport and
considerable variation has been found in the uptake schemes used by different bacterial …

Staphylococcus aureus is a Gram-positive pathogen responsible for tremendous morbidity
and mortality. As with most bacteria, S. aureus requires iron to cause disease, and it can …

The Isd (iron-regulated surface determinant) system is a multiprotein transporter that allows
bacterium Staphylococcus aureus to take up iron from hemoglobin (Hb) during human …

Absorption, magnetic circular dichroism (MCD), and electrospray mass spectral (ESI-MS)
data are reported for the heme binding NEAr iron Transporter (NEAT) domains of IsdA and …

Staphylococcus aureus is a prominent nosocomial pathogen and a major cause of
biomaterial-associated infections. The success of S. aureus as a pathogen is due in part to …

Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin
(Hb) represents the largest reservoir of iron, and pathogens express Hb-binding proteins to …

The cell wall envelope of Gram-positive pathogens functions as a scaffold for the attachment
of virulence factors and as a sieve that prevents diffusion of molecules. Here the isd genes …