Microorganisms have to cope with restricted iron bioavailability in most environmental
habitats as well as during host colonization. The continuous struggle for iron has brought …

Staphylococcus aureus is an extremely adaptable pathogen causing a wide variety of
infections. Staphylococcal surface proteins that directly interact with host extracellular …

As an important facet of host–pathogen interaction, Staphylococcus aureus has the ability to
adhere to human extracellular matrix (ECM) components via a range of surface proteins …

Iron holds a central position at the host–pathogen interface because mammalian and
microbial cells have an essential demand for the metal, which is required for many metabolic …

Iron is essential to virtually all organisms, but poses problems of toxicity and poor solubility.
Bacteria have evolved various mechanisms to counter the problems imposed by their iron …

The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled
expression of a diverse array of virulence factors. The effects of host environments on the …

Iron scarcity is one of the nutrition limitations that the Gram-positive infectious pathogens
Streptococcus pneumoniae encounter in the human host. To guarantee sufficient iron …

Staphylococcus aureus is able to grow in the presence of extremely low iron concentrations
(0.04 µM). In iron-limiting conditions, this species develops alternative metabolic strategies …

All but a few bacterial species have an absolute need for heme, and most are able to
synthesize it via a pathway that is highly conserved among all life domains. Because heme …

From a mass-excised Staphylococcus aureus λZapII expression library, we cloned an
operon encoding a novel ABC transporter with significant homology to bacterial siderophore …