Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Sperm deoxyribonucleic acid (DNA) damage has recently emerged as one of the most
controversial topics in male reproductive medicine. While level I evidence indicates that …

Sperm DNA fragmentation (sDF) represents a threat to male fertility, human reproduction
and the health of the offspring. The causes of sDF are still unclear, even if apoptosis …

DNA fragmentation, or the accumulation of single-and double-strand DNA breaks, is a
common property of sperm, and an increase in the level of sperm DNA fragmentation is …

We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Spermatozoa have the task to deliver an intact paternal genome to the oocyte and to support
a successful embryo development. The high levels of sperm DNA fragmentation (sDF) found …

Sperm DNA fragmentation is referred to as one of the main causes of male infertility. Failures
in the protamination process, apoptosis and action of reactive oxygen species (ROS) are …

Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male
fertility evaluation. While the essential role of sperm DNA integrity in human reproduction …

In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization
or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA …

Among the different DNA anomalies that can be present in the male gamete, DNA
fragmentation is the most frequent, particularly in infertile subjects. There is now consistent …