The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive
immune responses. IL-10 is elevated in the serum and tissues of patients with systemic …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a broad
spectrum of clinical presentations and association with multiple immunological …

Exposure of T cells to inflammatory cytokines leads to phosphorylation-dependent activation
of signal transducer and activator of transcription (STAT) 3. T cells from patients with …

The transcription factor STAT3 is overexpressed and hyperactivated in T cells from SLE
patients. STAT3 plays a central role in T cell differentiation into Th17 and T follicular helper …

Objective To assess the role of STAT4 activation in driving pathogenic follicular helper T
(Tfh) cell secretion of the cytokines interleukin‐21 (IL‐21) and interferon‐γ (IFNγ) in murine …

Ab maturation as well as memory B and plasma cell differentiation occur primarily in the
germinal centers (GCs). Systemic lupus erythematosus (SLE) may develop as a result of …

Background: IL-17 is an inflammatory cytokine that mediates immunopathology in
autoimmune disease. Results: DNA methylation at the il17 locus is lineage-restricted and …

Introduction: STAT4, which acts as the major signaling transducing STATs in response to IL-
12, is a central mediator in generating inflammation during protective immune responses …

Interleukin‐(IL‐) 10 and IL‐13 play important roles in Th2 cell differentiation and production
of autoantibodies in patients with (SLE). However, the mechanisms leading to IL10 and IL13 …

Objectives SLE is characterized by two pathogenic key signatures, type I IFN and B-cell
abnormalities. How these signatures are interrelated is not known. Type I-II IFN trigger …