Thermal processing has gained much interest in the pharmaceutical industry, particularly for
the enhancement of solubility, bioavailability, and dissolution of active pharmaceutical …

Formulation intervention, through the application of processing technologies, is a
requirement for enabling therapy for the vast majority of drugs. Without these enabling …

Thermal processing of amorphous solid dispersions continues to gain interest in the
pharmaceutical industry, as evident by several recently approved commercial products. Still …

A successful candidate for oral drug delivery needs to possess adequate solubility and
dissolution rate to elicit its therapeutic action. Extensive research is being carried out to …

Formulation of active pharmaceutical ingredients (API) in high-energy amorphous forms is a
common strategy to enhance solubility, dissolution rate and, consequently, oral …

Thermal manufacturing methods for the production of solid dispersions frequently require
the addition of a plasticizer in order to achieve requisite molten material flow properties …

Hot melt extrusion (HME) is a powerful technology to enhance the solubility and
bioavailability of poorly water-soluble drugs by producing amorphous solid dispersions …

Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

Hot-melt extrusion has found extensive application as a feasible pharmaceutical
technological option over recent years. HME applications include solubility enhancement …

Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable
from an economic and ecological perspective but also limited to thermostable active …