Antibody aggregation: insights from sequence and structure
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important
applications ranging from cancers, autoimmunity diseases and metabolic disorders to …
applications ranging from cancers, autoimmunity diseases and metabolic disorders to …
[HTML][HTML] Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics
In antibody development and manufacturing, protein aggregation is a common challenge
that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to …
that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to …
[HTML][HTML] Prediction and reduction of the aggregation of monoclonal antibodies
R van der Kant, AR Karow-Zwick, J Van Durme… - Journal of molecular …, 2017 - Elsevier
Protein aggregation remains a major area of focus in the production of monoclonal
antibodies. Improving the intrinsic properties of antibodies can improve manufacturability …
antibodies. Improving the intrinsic properties of antibodies can improve manufacturability …
[HTML][HTML] Competing aggregation pathways for monoclonal antibodies
H Wu, R Kroe-Barrett, S Singh, AS Robinson… - FEBS letters, 2014 - Elsevier
Aggregation is mediated by local unfolding to allow aggregation “hot spot (s)” to become
solvent exposed and available to associate with a hot spot on another partially unfolded …
solvent exposed and available to associate with a hot spot on another partially unfolded …
Engineering aggregation-resistant antibodies
JM Perchiacca, PM Tessier - Annual review of chemical and …, 2012 - annualreviews.org
The ability of antibodies to bind to target molecules with high affinity and specificity has led
to their widespread use in diagnostic and therapeutic applications. Nevertheless, a limitation …
to their widespread use in diagnostic and therapeutic applications. Nevertheless, a limitation …
Potential aggregation prone regions in biotherapeutics: a survey of commercial monoclonal antibodies
Aggregation of a biotherapeutic is of significant concern and judicious process and
formulation development is required to minimize aggregate levels in the final product …
formulation development is required to minimize aggregate levels in the final product …
Accelerated aggregation studies of monoclonal antibodies: considerations for storage stability
Aggregation of mAbs is a crucial concern with respect to their safety and efficacy. Among the
various properties of protein aggregates, it is emerging that their size can potentially impact …
various properties of protein aggregates, it is emerging that their size can potentially impact …
Investigation into temperature-induced aggregation of an antibody drug conjugate
NS Beckley, KP Lazzareschi, HW Chih… - Bioconjugate …, 2013 - ACS Publications
Conjugation of an antibody to a drug can produce heterogeneous species that may have
different physical stabilities and safety profiles. We explored the effect of thermal stress on …
different physical stabilities and safety profiles. We explored the effect of thermal stress on …
Aggregation, stability, and formulation of human antibody therapeutics
D Lowe, K Dudgeon, R Rouet, P Schofield… - Advances in protein …, 2011 - Elsevier
Many human monoclonal antibodies display poor biophysical properties, such as low
stability and a propensity to aggregate. These unfavorable tendencies can be even more …
stability and a propensity to aggregate. These unfavorable tendencies can be even more …
Linkers having a crucial role in antibody–drug conjugates
Antibody–drug conjugates (ADCs) comprised of a desirable monoclonal antibody, an active
cytotoxic drug and an appropriate linker are considered to be an innovative therapeutic …
cytotoxic drug and an appropriate linker are considered to be an innovative therapeutic …