This study introduces a novel analytical approach for studying aggregation and phase
separation of monoclonal antibodies (mAbs). The approach is based on using analytical …

The site-directed chemical conjugation of antibodies remains an area of great interest and
active efforts within the antibody–drug conjugate (ADC) community. We previously reported …

The focus of the antibody–drug conjugate (ADC) field is shifting toward development of site-
specific, next-generation ADCs to address the issue of heterogeneity, metabolic instability …

Abstract Antibody–drug conjugates (ADCs), which combine the specificity, favorable
pharmacokinetics, and biodistribution of a monoclonal antibody (mAb) with the cytotoxic …

Antibody drug conjugates (ADCs) are synthesized by conjugating a cytotoxic drug or
“payload” to a monoclonal antibody. The payloads are conjugated using amino or sulfhydryl …

The rise of antibodies as a promising and rapidly growing class of biotherapeutic proteins
has motivated numerous studies to characterize and understand antibody structures. In the …

The popularity of antibody drug conjugates (ADCs) has increased in recent years, mainly
due to their unrivalled efficacy and specificity over chemotherapy agents. The success of the …

In the past two decades, antibody–drug conjugates have gained increasing attention
because they expand the therapeutic index when compared with that of traditional …

Antibody-drug conjugates (ADCs) are a unique class of biotherapeutics of inherent
heterogeneity and correspondingly complex absorption, distribution, metabolism, and …

We investigate by kinetic analysis the aggregation mechanism of two monoclonal antibodies
belonging to the IgG1 and IgG2 subclass under thermal stress. For each IgG, we apply a …