Chronic pain is a serious condition that significantly impairs the quality of life, affecting an
estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial …

Background Neuropeptide Y (NPY) has been implicated in the modulation of pain. Under
normal conditions, NPY is found in interneurons in the dorsal horn of the spinal cord and in …

Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following
inflammation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of …

Our previous work indicates that the intrathecal administration of neuropeptide Y (NPY) acts
at its cognate receptors to reduce behavioral signs of nociception in several models of …

Neuropeptide Y (NPY) has an important but still insufficiently defined role in pain
modulation. We therefore examined the ability of NPY to modulate experimentally induced …

Neuropeptide Y (NPY) is believed to exert antinociceptive actions by inhibiting the release of
substance P and other 'pain neurotransmitters' in the spinal cord dorsal horn,,. However, the …

OBJECTIVE: Recent pharmacologic studies in our laboratory have suggested that the spinal
neuropeptide Y (NPY) Y1 receptor contributes to pain inhibition and to the analgesic effects …

Neuropeptide Y has been implicated in pain modulation and is substantially up-regulated in
dorsal root ganglia after peripheral nerve injury. To identify the role of neuropeptide Y after …

Neuropeptide Y (NPY) is expressed in certain primary afferent fibers, is up-regulated in
response to tissue injury and is capable of inhibiting nociceptive behavior at the spinal level …

Previous work has demonstrated that neuropeptide tyrosine (NPY), Y1 receptor and Y2
receptor are critical in modulation of pain after nerve injury. We hypothesized that NPY was …