An optimal host response against Staphylococcus aureus skin and soft tissue infections
(SSTI) is dependent on IL-1β and IL-17 mediated abscess formation. Alpha toxin (AT), an …

Elevated levels of bacteria, including biofilm, increase the risk of chronic wound infection
and inhibit healing. Addressing asymptomatic high bacterial loads is challenged by a lack of …

In contrast to normal healing wounds, chronic wounds commonly show disturbances in
proteins regulating wound healing processes, particularly those involved in cell proliferation …

The persistent inflammatory response at the wound site is a cardinal feature of nonhealing
wounds. Prolonged neutrophil presence in the wound site due to failed clearance by …

Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell
swelling, the protrusion of large bubbles from the plasma membrane and cell lysis. This …

Pore-forming toxins are the most common virulence factor in pathogenic bacteria. They lead
to membrane permeabilization and cell death. Herein, we show that respiratory epithelial …

Circulating neutrophils and monocytes form the first line of cellular defense against invading
bacteria. Here, we describe a novel and specific mechanism of disabling and eliminating …

Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes.
Microbial burden, or “bioburden,” is believed to underlie delayed healing, although little is …

Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and
by the release of cytokines, damage-and pathogen-associated molecular patterns. It plays …

Conspectus Diabetic foot ulcers (DFUs) are chronic wounds that develop in 30% of diabetic
patients. In DFUs, the normal wound healing process consisting of inflammation …