Background Genetic regulation of plasma lipids has been shown to influence the risk of
coronary artery disease (CAD). We analyzed the relationship between rs599839 and …

Recent genome-wide association studies (GWAS) have identified genetic variants
associated with coronary artery disease (CAD), ischemic stroke (IS) and serum lipid traits in …

Through genome-wide association studies, we have recently identified seven novel loci that
confer a substantial increase in risk for coronary artery disease (CAD). Elucidating the …

Abstract Background Many SNPs have been identified in genes regulating LDL-C
metabolism, but whether their influence is similar in subjects from different ethnicities is …

Background Recent genome-wide association studies (GWAS) have mapped several novel
loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic …

Aims Human genome-wide association studies (GWAS) have found that proline/serine-rich
coiled-coil 1 (PSRC1) encodes a protein that is associated with serum lipid levels and …

Objective—Genetic studies might provide new insights into the biological mechanisms
underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide …

Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular
disease,. Using genome-wide association data from three studies (n= 8,816 that included …

Background/Objective In Japanese populations, we performed a replication study of genetic
loci previously identified in European-descent populations as being associated with lipid …

Genome-wide association studies have the potential to lead to identification of novel
pathways and mechanisms for the pathogenesis of common complex diseases. Previous …