[HTML][HTML] Efficacy and treatment tolerance in older patients with NSCLC: a meta-analysis of five phase III randomized trials conducted by the Hellenic Oncology …

AG Pallis, A Karampeazis, L Vamvakas, N Vardakis… - Annals of oncology, 2011 - Elsevier
Background Approximately 50% of newly diagnosed cases of non-small-cell lung cancer
(NSCLC) are observed in patients> 65 years, while 30%–40% of cases occur in patients> 70 …

[HTML][HTML] Clinical outcomes and biomarker profiles of elderly pretreated NSCLC patients from the BATTLE trial

AS Tsao, S Liu, JJ Lee, C Alden… - Journal of Thoracic …, 2012 - Elsevier
Background Treating elderly non–small-cell lung cancer (NSCLC) patients in the salvage
setting is challenging because of concerns of intolerance to therapy. Here we report …

Non-small cell lung cancer in the elderly: defining treatment options

N Vora, KL Reckamp - Seminars in oncology, 2008 - Elsevier
Lung cancer is the leading cause of cancer deaths in the Western countries. Recent
advancements in the treatment of non-small cell lung cancer (NSCLC) have led to an …

Use of a comprehensive geriatric assessment for the management of elderly patients with advanced non–small-cell lung cancer: the phase III randomized ESOGIA …

R Corre, L Greillier, H Le Caër… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Comprehensive geriatric assessment (CGA) is recommended to assess the
vulnerability of elderly patients, but its integration in cancer treatment decision making has …

Treatment of older patients with advanced non-small cell lung cancer: a challenge

L Decoster, D Schallier - Journal of Geriatric Oncology, 2019 - Elsevier
With a median age of 70 years at diagnosis, lung cancer is a disease of older persons. As a
consequence oncologists are confronted with an increasing older lung cancer population for …

Do elderly patients with non-small cell lung cancer get the best out of recent advances in first-line treatment? A comparative study in two tertiary cancer centers in …

M Bakogeorgos, G Mountzios, E Bournakis… - Journal of Geriatric …, 2015 - Elsevier
Background Elderly patients with advanced non-small cell lung cancer (NSCLC) are thought
to receive suboptimal treatment mainly due to concerns for poor compliance and/or …

[HTML][HTML] Effectiveness and safety of afatinib, gefitinib, and erlotinib for treatment-naïve elderly patients with epidermal growth factor receptor-mutated advanced non …

LJ Hung, PC Hsu, CT Yang, CHS Kuo… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: In real-world practice, most patients with lung cancer are diagnosed when they
are aged≥ 65 years. However, clinical trials tend to lack data for the elderly population …

Molecular-targeted therapy for elderly patients with advanced non-small cell lung cancer

G Antonelli, M Libra, V Panebianco… - Oncology …, 2016 - spandidos-publications.com
Lung cancer is the most common cause of cancer-related mortality in men and women. Non‑
small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When …

Are EGFR tyrosine kinase inhibitors effective in elderly patients with EGFR-mutated non-small cell lung cancer?

G Roviello, L Zanotti, MR Cappelletti, A Gobbi… - Clinical and …, 2018 - Springer
EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib, gefitinib, and afatinib changed
dramatically the history of metastatic non-small cell lung cancer (NSCLC) harbouring EGFR …

Epidermal growth factor receptor‑tyrosine kinase inhibitors for non‑small‑cell lung cancer patients aged 80 years or older: A retrospective analysis

M Nakao, H Muramatsu, K Sone… - Molecular and …, 2015 - spandidos-publications.com
The efficacy of epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) in
elderly patients with non‑small‑cell lung cancer (NSCLC) remains uncertain. This …