In women breast cancer is still the most commonly diagnosed cancer. This type of cancer is
classified as a hormone-dependent tumor. Estrogen receptor (ER) expression and functional …

The estrogen receptor (ER) plays an important role in breast cancer development and
progression. Hypoxia has been shown to modulate the level of ERα expression, which is …

A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our
previous studies indicate that hypoxia-inducible factor 1α (HIF-1α) cooperates with ERα in …

Simple Summary In many types of cancers, the activity of the hypoxia-inducible factors
enhances hallmarks such as suppression of the immune response, altered metabolism …

The involvement of estrogen (E2) and hypoxia in tumor progression is well established.
Hypoxia has been reported to activate and degrade estrogen receptor alpha (ERα) in breast …

Background The transcription factor hypoxia-inducible factor-1 (HIF-1) is a key regulator of
the cellular response to hypoxia. Previous studies showed that concentrations of its subunit …

The estrogen receptor is one of the most important transcription factors in breast tumor
growth and development. We, and others, have previously shown that hypoxia induces rapid …

The development of intratumoral hypoxia is a universal hallmark of rapidly growing solid
tumors. Adaptation to the hypoxic environment, which is critical for tumor cell survival and …

The estrogen receptor (ER) is down-regulated under hypoxia via a proteasome-dependent
pathway. We studied the mechanism of ERα degradation under hypoxic mimetic conditions …

Under low oxygen conditions (hypoxia), cells activate survival mechanisms including
metabolic changes and angiogenesis, which are regulated by HIF-1. The estrogen-related …