The primary objective of this review is to give an overview of the main findings of the
European multicenter project “Patterns of Treatment Resistance and Switching Strategies in …

Objectives: The overview outlines two decades of research from the European Group for the
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …

A wide variety of definitions are used for Treatment Resistant Depression (TRD), considering
various criteria and different concepts. Some of the key issues are: the diagnosis, the …

Abstract Treatment-resistant depression refers to major depressive disorder, treatment of the
disorder, and failure to obtain an “acceptable” outcome. Regarding the disorder, the …

Objectives: Very few studies have investigated clinical features associated with treatment-
resistant depression (TRD) defined as failure of at least 2 consecutive antidepressant trials …

Background Few studies investigated socio-demographic and clinical predictors of non
response and remission in treatment resistant depression (TRD) in the case of failure of …

For over a decade, the European Group for the Study of Resistant Depression (GSRD) has
examined single nucleotide polymorphisms (SNP) and clinical parameters in regard to …

BackgroundTreatment-resistant depression (TRD) is the most problematic outcome of
depression in terms of functional impairment, suicidal thoughts and decline in physical …

Treatment-resistant depression (TRD) typically refers to inadequate response to at least one
antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence …

As many as 30% to 40% of patients with major depressive disorder are unresponsive to a
trial of antidepressant medication. Many patients labeled with treatment-resistant depression …