Objectives Clinical variables were investigated in the 'treatment resistant depression (TRD)‐
III'sample to replicate earlier findings by the European research consortium 'Group for the …

Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …

Background Major depressive disorder is a common, recurrent, disabling and costly disorder
that is often severe and/or chronic, and for which non-remission on guideline concordant first …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Treatment-resistant depression (TRD) continues to represent a major challenge for treating
clinicians. This report reviews the relevant literature to evaluate whether TRD can be …

The aim of the present study was to critically appraise current conceptual approaches;
demographic, neurobiological and clinical correlates; and management strategies of …

Background One-third of depressed patients develop treatment-resistant depression with the
related sequelae in terms of poor functionality and worse prognosis. Solid evidence …

Many association studies have reported associations between the catechol-O-
methyltransferase (COMT) gene and psychiatric disorders including major depression …

Background Treatment resistant depression is a complex disorder and an important source
of morbidity and mortality. Identification of risk factors of resistance may be useful to improve …

Major depressive disorder is a debilitating disease that imposes significant social and
economic burdens not only on patients but also on society. Although various treatment …