Up to 60% of patients with major depressive disorder (MDD) do not respond to the first
treatment with antidepressants. Response to antidepressants is a polygenic trait, although …

Major depressive disorder is one of the most prevalent and life-threatening forms of mental
illnesses and a major cause of morbidity worldwide. Currently available antidepressants are …

Objective: No universal definition for treatment-resistant depression (TRD) exists. This lack
of consensus reduces the generalizability of study findings and limits the ability to study …

BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …

There are currently no reliable approaches for correctly identifying which patients with major
depressive disorder (MDD) will respond well to antidepressant therapy. However, recent …

There is considerable diversity in how treatment-resistant depression (TRD) is defined.
However, every definition incorporates the concept that patients with TRD have not …

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

Objective: To describe treatment patterns in patients with treatment-resistant depression
(TRD) and major depressive disorder (MDD) stratified by depression severity and year of …

Abstract Treatment-Resistant Depression (TRD) represents a source of ongoing clinical and
nosological controversy and confusion. While no univocal consensus on its definition and …

Objective Indirect evidence suggests that common genetic variation contributes to individual
differences in antidepressant efficacy among individuals with major depressive disorder, but …