Treatment resistant depression (TRD) is a significant clinical and public health problem.
Among others, neuroplasticity and inflammatory pathways seem to play a crucial role in the …

BACKGROUND: Although genetic variants may play a key role in development of treatment-
resistant depression (TRD), relevant research is scarce. METHODS: To examine whether …

Repetitive transcranial magnetic stimulation (rTMS) is a painless and safe brain stimulation
technique that has been found to be effective in treating depression symptoms. The potential …

Several lines of evidence support an important genetic contribution to the wide individual
variation in therapeutic response to antidepressant medications. The Sequenced Treatment …

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

Pharmacogenetic testing is a useful and increasingly widespread tool to assist in
antidepressant prescription. More than ten antidepressants (including tricyclics, selective …

In the post-genomic era, genetics has led to limited clinical applications in the diagnosis and
treatment of major depressive disorder (MDD). Variants in genes coding for cytochrome …

Although there is a wide variety of antidepressants with different mechanisms of action
available, the efficacy of treatment is not satisfactory. Genetic factors are presumed to play a …

Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-
economic burden. Antidepressants of different classes are prescribed to treat MDD, but …

Context The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3
patients does not fully recover even after several treatment trials. Genetic factors and clinical …