BACKGROUND The mission of the National Cancer Institute's Early Detection Research
Network (EDRN) is to identify and validate cancer biomarkers for clinical use. Since its …

BACKGROUND The National Cancer Institute's Early Detection Research Network (EDRN)
has made significant progress in developing an organized effort for discovering and …

Rigorous validation of biomarkers for early detection of cancer differs at the National Institute
of Standards and Technology (NIST) from similar processes common among research …

The cancer early-detection biomarker field was, compared with the therapeutic arena, in its
infancy when the Early Detection Research Network (EDRN) was initiated in 2000. The …

Abstract In 2000, the NCI (Rockville, MD) established the Early Detection Research Network
(EDRN) to identify, develop, and validate biomarkers to improve the detection of early-stage …

Validation of early detection cancer biomarkers has proven to be disappointing when initial
promising claims have often not been reproducible in diagnostic samples or did not extend …

Background The introduction of new biomarkers can lead to inappropriate utilization of tests
if they do not fill in existing gaps in clinical care. We aimed to define a strategy and checklist …

The application of “omics” technologies to biological samples generates hundreds to
thousands of biomarker candidates; however, a discouragingly small number make it …

Comprehensive Biomarker Discovery and Validation for Clinical Application provides the
reader with an extensive introduction into all aspects of proteomics biomarker discovery …

The last decade has seen an extraordinary amount of effort devoted in biomedical research
to the field of biomarkers. There have been some notable successes with novel markers …