Methods: In a preliminary pharmacodynamic study in the pig, tricarbonylchloro (glycinato)
ruthenium (II)(CORM-3) was administered as a single dose of 4 mg/kg iv into two Large …

Background: Carbon monoxide (CO) interferes with inflammatory and apoptotic processes
associated with ischemia–reperfusion injury and graft rejection. Here, the in vitro effects of …

Background. The protective effects of carbon monoxide (CO) against ischemia/reperfusion
(IR) injury during organ transplantation have been extensively investigated. Likewise, CO …

Background. CO-releasing molecule-3 (CORM-3) is a transitional metal carbonyl that
liberates carbon monoxide under appropriate conditions. Carbon monoxide exerts effects on …

Carbon monoxide (CO) can provide beneficial antiapoptotic and anti-inflammatory effects in
the context of ischemia–reperfusion injury (IRI). Here we tested the ability of pretreating the …

Methods: We used a murine intestinal I/R injury model. Intestinal ischemia was introduced
by clamping superior mesenteric artery with atraumatic plastic clip in male C57BL/6 mice …

METHODS Adult pig kidneys (8) were procured following 1 hr cross clamping of renal
arteries. Organs were flushed with cold HTK solution and stored in cold pulsatile perfusion …

Background Carbon monoxide (CO) inhalation protects organ by reducing inflammation and
cell death during transplantation processes in animal model. However, using CO in clinical …

Xenotransplantation may be a future alternative due to increased shortage of organs.
Classical complement activation is central in hyperacute rejection in pig-to-human …

ObjectiveTo investigate the effect and underling mechanism of water-soluble CO-releasing
molecules (CORM-3) on the alleviation of allograft rejectionafter mouse kidney …