R-loops have been described at immunoglobulin class switch sequences, prokaryotic and
mitochondrial replication origins, and disease-associated (CAG) n and (GAA) n trinucleotide …

Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …

R-loops, transcriptionally-induced RNA: DNA hybrids, occurring at repeat tracts (CTG)
n,(CAG) n,(CGG) n,(CCG) n and (GAA) n, are associated with diseases including myotonic …

Models for the disease-associated expansion of (CTG) n·(CAG) n,(CGG) n·(CCG) n, and
(GAA) n·(TTC) n trinucleotide repeats involve alternative DNA structures formed during DNA …

R-loops have been described in vivo at the immunoglobulin class switch sequences and at
prokaryotic and mitochondrial origins of replication. However, the biochemical mechanism …

R-loops form when transcribed RNA remains bound to its DNA template to form a stable
RNA: DNA hybrid. Stable R-loops form when the RNA is purine-rich, and are further …

Within the last 6–8 years, the remarkable revelation that many neurodegenerative diseases
are caused by the expansion of triplet repeats has prompted a great deal of research …

Triplet repeat expansion diseases (TREDs) are characterized by the coincidence of disease
manifestation with amplification of d (CAG· CTG), d (CGG· CCG) or d (GAA· TTC) repeats …

Recent molecular genetics studies have revealed a correlation between spontaneous,
progressive expansion of several DNA trinucleotide repeats and certain hereditary …

The three-stranded nucleic acid structure, R-loop, is increasingly recognized for its role in
gene regulation. Initially, R-loops were thought to be the by-products of transcription; but …