Adequate tissue sampling is known to reduce the likelihood that the toxicity of novel
biomolecules, chemicals, and drugs might go undetected. Each organ, and often specific …

This session at the 2010 joint symposium of the Society of Toxicologic Pathology (STP) and
the International Federation of Societies of Toxicologic Pathologists (IFSTP) explored …

This review article is designed to serve as an introductory guide in neuroanatomy for
toxicologic pathologists evaluating general toxicity studies. The article provides an overview …

Xenobiotic-induced neuroanatomic alterations are always regarded as adverse and are
commonly used to define reference doses to manage neurotoxic risk. Thus, the …

Although manuscripts for multiple species recommending nervous system sampling for
histopathology evaluation in safety assessment have been published in the past 15 years …

Neurotoxicology is a major focus of scientists and policy makers. Neurotoxicological
investigations provide vital information needed by regulatory scientists to protect public …

Sampling of large-sized brains (eg, dog, primate) for microscopic examination is frequently
inadequate to detect localized neurotoxic injury. Furthermore, the examination of H&E …

Neuropathology remains the benchmark to detect neurotoxicity in animal toxicology studies.
Along with neurobehavioral endpoints, morphological changes are used to identify or …

This article outlines the changes and underlying rationale for modifications to the
histopathological evaluation of the nervous system during toxicology and carcinogenesis …

The developmental neuropathology examination in juvenile toxicity studies depends on the
nature of the product candidate, its intended use, and the exposure scenario (eg, dose …