Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction
of ligand-induced dimers of intact receptor tyrosine kinase, KIT. We observe that KIT …

Summary Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the
ectodomain of KIT, resulting in tyrosine kinase activation. We describe the crystal structure of …

In this issue, Schlessinger and his colleagues (Yuzawa et al., 2007) describe crystal
structures of the complete extracellular region of the Kit receptor tyrosine kinase, both alone …

KIT receptor kinase activity is repressed, prior to stem cell factor binding, by unknown
structural constraints. Using site-directed mutagenesis, we examined the role of KIT …

The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …

Signaling by stem cell factor and Kit, its receptor, plays important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …

Signal transduction across biological membranes ubiquitously involves a receptor
oligomerization step. Although the necessity of this process was functionally demonstrated …

ABSTRACT Kit‐ligand (Kitl), also known as stem cell factor, is a membrane‐anchored,
noncovalently bound dimer signaling via the c‐kit receptor tyrosine kinase, required for …

Most growth factors and cytokines activate their receptors by inducing dimerization upon
binding. We have studied binding of the dimeric cytokine stem cell factor (SCF) to the …

Stem cell factor (SCF) binds to and activates the KIT receptor, a class III receptor tyrosine
kinase (RTK), to stimulate diverse processes including melanogenesis, gametogenesis and …