Keratinocyte growth factor (KGF) caused cystic dilation of mouse fetal lung explants in vitro,
markedly increasing the luminal volume of lung buds and disrupting branching …

Introduction Lung fluid clearance is essential for successful postnatal pulmonary adaptation.
The epithelial sodium channel (ENaC) and Na‐K‐ATPase, induced by serum‐and …

Glucocorticoid hormones play an important role in fetal lung maturation. It is unknown how
they interact with changes in O2 tension, which play an important role in converting the lung …

At birth, the infant's lungs must be cleared of fetal lung fluid. This process is mediated
through the activation of airway epithelial sodium channels (ENaC). In animals, ENaC is …

Abstract Background Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome
(RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was …

Intra-amniotic exposure to proinflammatory cytokines such as interleukin-1 (IL-1) correlates
with a decreased incidence of respiratory distress syndrome (RDS) in infants following …

At birth, lung fluid produced during fetal life must be cleared immediately and efficiently
before the first breath takes place, in order for infants to achieve a normal and successful …

Objective. Active ion transport is critical to postnatal clearance of lung fluid. The importance
of epithelial sodium channel (ENaC) in this clearance has been demonstrated in animal …

Near the end of gestation, the direction of ion and fluid flow across the alveolar epithelium
rapidly changes from secretion to absorption. Thus, the relative cell membrane location of …

BACKGROUND: Glucocorticoids have profound effects on lung maturation and function. In
in vitro and animal models, they induce epithelial sodium channels (ENaCs) in the airway …