Alveolar type II cells were isolated from late-term fetal sheep to investigate ion transport
across fetal distal lung epithelium. In Ussing chambers, basal transepithelial potential …

Intrauterine inflammation generates inflammatory mediators that damage the developing
bronchoalveolar epithelium, resulting in neonatal lung injury. Lung fluid transport disorders …

Female sex predisposes individuals to poorer outcomes during respiratory disorders like
cystic fibrosis and influenza-associated pneumonia. A common link between these disorders …

We evaluated the effects of acute hyperoxic exposure on alveolar epithelial cell (AEC) active
ion transport and on expression of Na+ pump (Na+-K+-ATPase) and rat epithelial Na+ …

Noninfective acute respiratory disease develops in approximately 1% of all newborn infants
and results in their admission to a critical care unit. Transient tachypnea of the newborn …

Extracellular matrix (ECM) synthesized by the fetal mesenchymal cells provides a supporting
structure for the growing airways and is important for airway branching and in the …

Pulmonary epithelial Na+ channels (ENaC), composed of three distinct subunits (alpha,
beta, and gamma), play a critical role in the regulation of fluid reabsorption from airspaces of …

At birth, the lungs must immediately assume the essential job of gas exchange. There are
many associated environmental changes taking place at birth, including an approximate …

Lung epithelial cell differentiation is predominantly regulated by mesenchymal-epithelial cell
communication. We have previously shown that epidermal growth factor (EGF) positively …

Airway liquid content and insufficient absorptive airway ion transport at birth are potentially
important factors in the development and severity of neonatal respiratory disease. The role …