Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin‐induced toxicity in primary cultures of cerebellar granule neurons of rats

S González-Reyes, S Guzmán-Beltrán… - Oxidative medicine …, 2013 - Wiley Online Library
Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies
curcumin as a neuroprotectant against hemin‐induced damage in primary cultures of …

Curcumin activates defensive genes and protects neurons against oxidative stress

G Scapagnini, C Colombrita, M Amadio… - Antioxidants & redox …, 2006 - liebertpub.com
Spices and herbs often contain active phenolic substances endowed with potent
antioxidative properties. We had previously shown that curcumin, the yellow pigment in …

Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain

A Ataie, M Sabetkasaei, A Haghparast… - Journal of medicinal …, 2010 - liebertpub.com
Aging is the major risk factor for neurodegenerative diseases and oxidative stress and is
involved in their pathophysiology. Oxidative stress can induce neuronal damage and …

Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway

Q Cui, X Li, H Zhu - Molecular medicine reports, 2016 - spandidos-publications.com
Parkinson's disease (PD) is an age‑related complex neurodegenerative disease that
affects≤ 80% of dopaminergic neurons in the substantia nigra pars compacta (SNpc). It has …

Curcumin protects mouse neuroblastoma Neuro-2A cells against hydrogen-peroxide-induced oxidative stress

XC Zhao, L Zhang, HX Yu, Z Sun, XF Lin, C Tan, RR Lu - Food Chemistry, 2011 - Elsevier
Curcumin has been traditionally used in China and India for food and medicinal purposes. It
has been shown to possess potent antioxidative activity both in vitro and in vivo. In the …

Curcumin and heme oxygenase: neuroprotection and beyond

E Mhillaj, A Tarozzi, L Pruccoli, V Cuomo… - International journal of …, 2019 - mdpi.com
Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently
considered one of the most effective nutritional antioxidants for counteracting free radical …

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

S Abrahams, WL Haylett, G Johnson, JA Carr… - Neuroscience, 2019 - Elsevier
The global burden of neurodegenerative disorders has increased substantially over the past
2 decades due to rising rates of population aging. Although neurodegenerative disorders …

RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity

I Carmona-Ramírez, A Santamaría, JC Tobón-Velasco… - 2013 - Elsevier
Neurological diseases comprise a group of heterogeneous disorders characterized by
progressive brain dysfunction and cell death. In the next years, these diseases are expected …

Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat

A Ataie, M Sabetkasaei, A Haghparast… - Pharmacology …, 2010 - Elsevier
Aging is the major risk factor for neurodegenerative diseases and oxidative stress is
involved in the pathophysiology of these diseases. In this study, the possible antioxidant and …

Curcumin has neuroprotection effect on homocysteine rat model of Parkinson

Z Mansouri, M Sabetkasaei, F Moradi… - Journal of Molecular …, 2012 - Springer
Parkinson's disease (PD) is a progressive neurological disorder which is emanated by
dopaminergic death cell and depletion. Curcumin as a nontoxic matter has antioxidant, anti …