Bcl‐2 protein plays a critical role in inhibiting anticancer drug‐induced apoptosis, which is
mediated by a mitochondria‐dependent pathway that controls the release of cytochrome c …

Bcl-2 is an oncoprotein that plays a critical role in inhibiting apoptotic cell death in the
mitochondria-dependent pathway in cancer chemotherapy. As a strategy for blocking Bcl-2 …

Ever since its implication in multidrug chemoresistance in tumors, the bcl-2 gene (also
known as BCL2) has stood out among molecular targets in oncology (1). The protein …

BACKGROUND Because bcl‐2 is a critical factor for anticancer drug‐induced apoptosis, the
authors conducted a preclinical evaluation of antisense (AS) bcl‐2 as an enhancer of the …

Bcl-2 is an apoptosis regulating protein, overexpression of which is associated with
chemotherapy resistant disease, aggressive clinical course, and poor survival in patients …

High expression of the bcl-2 proto-oncogene is found in various human hematologic
malignancies and solid tumors. Bcl-2 protein exerts its oncogenic role by preventing tumor …

Apoptosis, or programmed cell death, is a complex process of cell turnover involved in both
normal and pathologic processes in the body. Impairments in the apoptotic pathways …

The bcl-2 gene is expressed in many types of human tumors and becomes transcriptionally
deregulated in the majority of non-Hodgkin's lymphomas as the result of t (14; 18) …

Regulation of cell death (apoptosis) is frequently affected in the development of malignant
diseases, and all molecular steps from extracellular signalling receptors through intracellular …

The targeting of anti-apoptotic members of the Bcl-2 family of proteins, especially Bcl-2, is
the focus of efforts to modulate the intrinsic pathway of apoptosis and effect tumor death …