The objectives of this article were to review the mechanism and clinical significance of
statins-macrolides interaction, determine which combination has the highest risk for the …

Purpose Statins are among the most frequently prescribed medications internationally. Older
people are commonly prescribed multiple medications and are at an increased risk of drug …

The 2013 ACC/AHA guidelines on blood cholesterol management were a major shift in the
delineation of the main patient groups that could benefit from statin therapy and emphasized …

The risks of muscle adverse events related to use of the 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase inhibitors, or statins, increase significantly with the …

In this mini-review, the evidence for safety and efficacy of currently available statins is
discussed. Large-scale, long-term clinical studies have documented an outstanding efficacy …

Background It is important to understand patients' experiences of statin-associated adverse
effects to potentially identify those at risk for stopping treatment. Objective The goal of the …

Statin-associated adverse effects, primarily muscle-related symptoms, occur in up to
approximately one-third of patients in clinical practice. Recently, a Canadian Consensus …

This article summarizes the final conclusions of the National Lipid Association (NLA) Statin
Safety Task Force, based on a review and independent research of New Drug Application …

Introduction The myopathy risk associated with statin use increases in case of concomitant
prescription of certain drugs, such as cytochrome P 450 (CYP) system inhibitors (ie …

Safety has become a central issue in the management of dyslipidemia with statins. A review
of New Drug Applications (NDAs) and the US Food and Drug Administration (FDA) Web site …