Women with reduced ovarian reserve or advanced maternal age have an altered metabolic
follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post …

The maintenance of metabolic homeostasis requires the well-orchestrated network of
several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these …

Abstract STUDY QUESTION Does Sirt3 dysfunction result in poor developmental outcomes
for human oocytes after in vitro maturation (IVM)? SUMMARY ANSWER Inefficient Sirt3 …

The energy production and metabolic homeostasis are well-orchestrated networks of
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …

Reproduction is the way to immortality for an individual, and it is essential to the continuation
of the species. Sirtuins are involved in cellular homeostasis, energy metabolism, apoptosis …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

Mitochondria play a central role in the production of reactive oxygen species as byproducts
of metabolism and energy production. In order to protect cellular structures from oxidative …

Significance: Maintenance of metabolic homeostasis is critical for cellular and organismal
health. Proper regulation of mitochondrial functions represents a crucial element of overall …

The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …