The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern,
and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is …

Sirtuins comprise a family of nicotinamide adenine dinucleotide (NAD+)-dependent lysine
deacylases that regulate the life span, aging, and metabolism. Seven sirtuin family members …

In addition to serving as the power house of mammalian cells, mitochondria are crucial for
the maintenance of cellular homeostasis in response to physiological or environmental …

Background Ovarian function is closely related to the degree of vascular network
development surrounding the ovary. Maternal aging‐related construction defects in this …

The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major
aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive …

STUDY QUESTION Is the activity of sirtuin 3 (SIRT3) altered in granulosa and cumulus cells
from young women with reduced ovarian reserve or women of advanced maternal age …

Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin
research has focused on SirT1, which deacetylates transcription factors and cofactors in the …

SIRT 4 modulates energy homeostasis in multiple cell types and tissues. However, its role in
meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT …

Sirtuins are the endogenously present anti-aging protein deacetylases that regulate the
mitochondrial biogenesis and function. Especially Sirt3, a mitochondrial sirtuin, is well …

Abstract Sirtuin 3 (SIRT3), the main family member of mitochondrial deacetylase, targets the
majority of substrates controlling mitochondrial biogenesis via lysine deacetylation and …