Abstract Sirtuin1 (SIRT1) and Sirtuin3 (SIRT3) protects cardiac function against
ischemia/reperfusion (I/R) injury. Mitochondria are critical in response to myocardial I/R …

Sirtuins belong to the class III family of NAD-dependent histone deacetylases (HDAC) and
are involved in diverse physiological processes that range from regulation of metabolism …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Background Diabetes mellitus (DM)-related complications are important health problems
worldwide. The underlying mechanisms for diabetic male subfertility/infertility are …

The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-
dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular …

Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in
mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest …

Sirtuins (Sirts) are implicated in regulating a myriad of biologic functions ranging from cell
growth and metabolism to longevity. Here, we show that nuclear Sirt, Sirt6, and …

Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide
(NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in …

Sirtuin 3, a member of the mammalian sirtuin family of proteins, is involved in the regulation
of multiple processes in cells. It is a major mitochondrial NAD+-dependent deacetylase with …

Signaling pathways between mitochondrial and nuclear genomes are activated to preserve
cellular homeostasis, especially in the event of stress. Using cybrid cell lines, we …