Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.
LK Gilliland, MR Clark… - Proceedings of the …, 1988 - National Acad Sciences
Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell
fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill …
fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill …
Retargeting of cytolytic T lymphocytes by heteroaggregated (bispecific) antibodies.
IG Barr, F Buchegger, HR MacDonald… - Cancer Detection and …, 1988 - europepmc.org
The specificity and efficiency of tumor cell lysis by the retargeting of murine and human
cytolytic T lymphocytes (CTL) with heteroaggregated (also known as bispecific or hybrid) …
cytolytic T lymphocytes (CTL) with heteroaggregated (also known as bispecific or hybrid) …
Targeted cellular immunotherapy with bifunctional antibodies.
H Nelson - Cancer Cells (Cold Spring Harbor, NY: 1989), 1991 - europepmc.org
Linking an antitumor cell antibody with an antilymphocyte antibody produces a bifunctional
antibody that can redirect T lymphocytes to lyse tumor cells. Bifunctional antibodies that …
antibody that can redirect T lymphocytes to lyse tumor cells. Bifunctional antibodies that …
Targeting of cytotoxic cells with heterocrosslinked antibodies
DM Segal, JR Wunderlich - Cancer Investigation, 1988 - Taylor & Francis
Cytotoxic cells express specific receptors on their sur-faces by which they distinguish altered
or foreign cells from normal autologous cells. These receptors form multiple links to …
or foreign cells from normal autologous cells. These receptors form multiple links to …
Lysis of tumor cells by the retargeting of murine cytolytic T lymphocytes with bispecific antibodies
IG Barr, HR MacDonald, F Buchegger… - … journal of cancer, 1987 - Wiley Online Library
The specificity and efficiency of tumor‐cell lysis by the retargeting of murine cytolytic
lymphocytes (CTL) with bispecific antibodies was examined. Bispecific antibodies (also …
lymphocytes (CTL) with bispecific antibodies was examined. Bispecific antibodies (also …
T-Cell Retargeting Using Bispecific Monoclonal Antibodies in a Rat Colon Carcinoma Model. I. Significant Bispecific Lysis of Syngeneic Colon Carcinoma CC531 Is …
GDM Beun, JDH van Eendenburg… - Journal of …, 1992 - journals.lww.com
In order to develop a rat model that reflects human weakly or nonimmunogenic tumor-host
relationships and allows investigation of T-cell retargeting with bispecific monoclonal …
relationships and allows investigation of T-cell retargeting with bispecific monoclonal …
[引用][C] Targeted cytotoxic cells as a novel form of cancer immunotherapy
DM Segal, MA Garrido, P Perez, JA Titus… - Molecular …, 1988 - Elsevier
Cellular cytotoxicity is mediated by receptors on the surfaces of cytotoxic cells (lysis
promoting receptors) which are specific for cell surface components on target cells. Such …
promoting receptors) which are specific for cell surface components on target cells. Such …
Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity.
UD Staerz, MJ Bevan - … of the National Academy of Sciences, 1986 - National Acad Sciences
Previous studies have shown that heteroconjugates of monoclonal antibodies in which one
of the component antibodies is directed at the T-cell receptor and the other is directed …
of the component antibodies is directed at the T-cell receptor and the other is directed …
T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. II. Syngeneic colon carcinoma CC531 is efficiently killed by retargeted …
GD Beun, A Gorter, Y Nooyen… - … (Baltimore, Md.: 1950 …, 1993 - journals.aai.org
We have previously described the generation of bispecific anti-TCR* anti-tumor mAb,
intended for in vivo analysis of T cell retargeting in a syngeneic rat colon carcinoma model …
intended for in vivo analysis of T cell retargeting in a syngeneic rat colon carcinoma model …
Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes.
MA Liu, DM Kranz, JT Kurnick… - Proceedings of the …, 1985 - National Acad Sciences
Antibodies to the clonally unique variable-region determinants (idiotype) of the antigen-
specific alpha beta heterodimeric receptor of a clone of cytotoxic T cells (CTLs) were shown …
specific alpha beta heterodimeric receptor of a clone of cytotoxic T cells (CTLs) were shown …