Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans

J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …

[HTML][HTML] A Conserved Gcn2-Gcn4 Axis Links Methionine Utilization and the Oxidative Stress Response in Cryptococcus neoformans

AK Stovall, CM Knowles, MC Kalem… - Frontiers in fungal …, 2021 - frontiersin.org
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …

Cryptococcus neoformans, a fungus under stress

SM Brown, LT Campbell, JK Lodge - Current opinion in microbiology, 2007 - Elsevier
Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses
during growth in the human host, including oxidative and nitrosative stress, high …

RNA biology and the adaptation of Cryptococcus neoformans to host temperature and stress

ALM Bloom, JC Panepinto - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
Cryptococcus neoformans is an environmental fungus that can cause severe disease in
humans. C. neoformans encounters a multitude of stresses within the human host to which it …

Global Transcriptome Profile of Cryptococcus neoformans during Exposure to Hydrogen Peroxide Induced Oxidative Stress

R Upadhya, LT Campbell, MJ Donlin, R Aurora… - PloS one, 2013 - journals.plos.org
The ability of the opportunistic fungal pathogen Cryptococcus neoformans to resist oxidative
stress is one of its most important virulence related traits. To cope with the deleterious effect …

mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans

ALM Bloom, J Leipheimer… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Fungi are ubiquitous in the environment and humans constantly encounter them in the soil,
air, water, and food. The vast majority of these interactions are inconsequential. However, in …

Cdk8 and Ssn801 Regulate oxidative stress resistance and virulence in Cryptococcus neoformans

AL Chang, Y Kang, TL Doering - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

Tools for Assessing Translation in Cryptococcus neoformans

CM Knowles, KM McIntyre, JC Panepinto - Journal of Fungi, 2021 - mdpi.com
Cryptococcus neoformans is a ubiquitous environmental fungus capable of establishing an
infection in a human host. Rapid changes in environments and exposure to the host immune …

Remodeling of Global Transcription Patterns of Cryptococcus neoformans Genes Mediated by the Stress-Activated HOG Signaling Pathways

YJ Ko, YM Yu, GB Kim, GW Lee, PJ Maeng, S Kim… - Eukaryotic …, 2009 - Am Soc Microbiol
The ability to sense and adapt to a hostile host environment is a crucial element for virulence
of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are …

Posttranslational, Translational, and Transcriptional Responses to Nitric Oxide Stress in Cryptococcus neoformans: Implications for Virulence

TA Missall, ME Pusateri, MJ Donlin, KT Chambers… - Eukaryotic …, 2006 - Am Soc Microbiol
The ability of the fungal pathogen Cryptococcus neoformans to evade the mammalian innate
immune response and cause disease is partially due to its ability to respond to and survive …