The ability of the fungal pathogen Cryptococcus neoformans to evade the mammalian innate
immune response and cause disease is partially due to its ability to respond to and survive …

In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under
stress conditions. During temperature adaptation in the human fungal pathogen …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Cryptococcus neoformans and its sister species Cryptococcus deuterogattii are important
human fungal pathogens. Despite their phylogenetically close relationship, these two …

Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …

The sophisticated ability of living organisms to sense and respond to external stimuli is
critical for survival. This is particularly true for fungal pathogens, where the capacity to adapt …

The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

Adaptation to host temperature is a prerequisite for any pathogen capable of causing deep
infection in humans. Our previous studies demonstrated that a Cryptococcus neoformans …

Adaptation to external environmental challenges at the cellular level requires rapid
responses and involves relay of information to the nucleus to drive key gene expression …