ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) inhibitors are widely used as first-
line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an …

Abstract Background The phosphodiesterase-5 (PDE5) inhibitors that have been available
for nearly 20 years are highly effective in treating erectile dysfunction and have been …

Phosphodiesterase (PDE) enzymes are widely distributed throughout the body, having
numerous effects and functions. The PDE type 5 (PDE5) inhibitors are widely used to treat …

Phosphodiesterase 5 inhibitors, such as sildenafil, vardenafil and tadalafil, are now
approved for the treatment of erectile dysfunction. They inhibit the cGMP-specific isoform 5 of …

Phosphodiesterase type-5 (PDE5) inhibitors are widely used as first-line therapy for erectile
dysfunction (ED). Their efficacy and safety combined with an increasing understanding of …

The coexistence of cardiovascular disease and erectile dysfunction is widespread, possibly
owing to underlying endothelial dysfunction in both diseases. Millions of patients with …

Abstract Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate
monophosphate specifically to 5′ guanylate monophosphate, promoting corporeal …

J Clin Hypertens (Greenwich). 2012; 14: 644–649.© 2012 Wiley Periodicals, Inc.
Phosphodiesterase 5 (PDE‐5) inhibitors are selective blockers of PDE‐5, which catalyzes …

Erectile dysfunction (ED) has been revolutionized during the last two decades, as several
treatment options are available today. Phosphodiesterase type 5 (PDE5) inhibitors …

Abstract PDE5 inhibitors (PDE5i) are widely known as treatment for erectile dysfunction
(ED). This favorable action has emerged as a “side effect” from pioneering studies when …