Objective To compare with placebo the efficacies of once-daily administrations of lacidipine
and hydrochlorothiazide separately and in combination to elderly patients with systolic …

Objective: Our aim was to compare the effect of lacidipine and chlorthalidone on
cardiovascular outcome as a primary parameter and blood pressure as a secondary in …

Elderly patients are becoming a greater proportion of the hypertensive population. In
addition, they may respond differently to drugs, both pharmacodynam-ically and …

Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications
(ie, cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation …

One hundred seventy‐one patients, 60 years of age or older with isolated systolic
hypertension, were randomly assigned to receive chlorthalidone 12.5, 25.0, or 50.0 mg or …

Abstract The Systolic Hypertension in the Elderly Program (SHEP) is a randomized, blinded
test of the efficacy of antihypertensive drug treatment. In a large feasibility trial, 551 men and …

Recent multicenter trials have demonstrated that, in hypertensive elderly people, blood
pressure control can significantly decrease the rate of cardiovascular and cerebrovascular …

A multicenter, double-blind, placebo-controlled trial with multifactorial design was conducted
to evaluate the safety and efficacy of the calcium-channel blocker diltiazem, in a sustained …

This study was aimed at evaluating the antihypertensive effect of lisinopril and
hydrochlorothiazide administered in the fixed combination of 20 and 12.5 mg, respectively …

The risks of hypertension in the elderly, including increased morbidity and mortality rates
from stroke, congestive heart failure, coronary heart disease, peripheral vascular disease …