Notch dimerization is required for leukemogenesis and T-cell development
Notch signaling regulates myriad cellular functions by activating transcription, yet how Notch
selectively activates different transcriptional targets is poorly understood. The core Notch …
selectively activates different transcriptional targets is poorly understood. The core Notch …
Genome-wide identification and characterization of Notch transcription complex–binding sequence-paired sites in leukemia cells
Notch transcription complexes (NTCs) drive target gene expression by binding to two distinct
types of genomic response elements, NTC monomer–binding sites and sequence-paired …
types of genomic response elements, NTC monomer–binding sites and sequence-paired …
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia
Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute
lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in …
lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in …
[HTML][HTML] NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function
A Yatim, C Benne, B Sobhian, S Laurent-Chabalier… - Molecular cell, 2012 - cell.com
Activating mutations in NOTCH1, an essential regulator of T cell development, are frequently
found in human T cell acute lymphoblastic leukemia (T-ALL). Despite important advances in …
found in human T cell acute lymphoblastic leukemia (T-ALL). Despite important advances in …
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
AP Weng, JM Millholland, Y Yashiro-Ohtani… - Genes & …, 2006 - genesdev.cshlp.org
Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …
NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes
by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor …
by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor …
Notch in leukemia
AC McCarter, Q Wang, M Chiang - Molecular mechanisms of notch …, 2018 - Springer
Notch is commonly activated in lymphoid malignancies through ligand-independent and
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …
ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) …
Notch signalling at the crossroads of T cell development and leukemogenesis
AF Campese, D Bellavia, A Gulino… - Seminars in cell & …, 2003 - Elsevier
Members of the Notch family (eg Notch1 and Notch3) have been recently described to play a
critical role in T cell development and their constitutive activation has been related to T cell …
critical role in T cell development and their constitutive activation has been related to T cell …
Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis
P Gómez-del Arco, M Kashiwagi, AF Jackson, T Naito… - Immunity, 2010 - cell.com
Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell
acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We …
acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We …
The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia
Notch is a major oncogenic driver in T cell acute lymphoblastic leukemia (T-ALL), in part
because it binds to an enhancer that increases expression of MYC. Here, we exploit the …
because it binds to an enhancer that increases expression of MYC. Here, we exploit the …