The production of nitric oxide (NO) by the inducible NO synthase (iNOS) is a key defense
mechanism against intracellular pathogens such as Leishmania. Numerous studies have …

Nitric oxide (NO) production is critical for the host defense against intracellular pathogens;
however, it is unclear whether NO-dependent control of intracellular organisms depends on …

Previous studies with inhibitors of inducible nitric oxide synthase (iNOS) suggested that high-
output production of nitric oxide (NO) is an important antimicrobial effector pathway in vitro …

Constitutive nitric oxide (NO) is generated by constitutively expressed types of NO-synthase
enzymes (NOS-I and-III), being involved in physiological processes such as nervous …

Type 2 nitric oxide synthase (NOS2) is required for the Th1-dependent healing of infections
with intracellular microbes, including Leishmania major. Here, we demonstrate the …

Nitric oxide (NO) produced by an inducible nitric oxide synthase (iNOS or NOS2) plays a
major microbicidal role in murine macrophages and its importance is now emerging also in …

To discover how nitric oxide (NO) synthesis is controlled in different tissues as cells within
these tissues combat intracellular pathogens, we examined three distinctively different …

ABSTRACT Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for
the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast …

Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …

In mammalian hosts, Leishmania parasites are obligatory intracellular organisms that invade
macrophages (Mϕ) and dendritic cells (DC). In Mϕ, the production of nitric oxide (NO) …