It is well established that the risk to develop neurodegenerative disorders increases with
chronological aging. Accumulating studies contributed to characterize the age-dependent …

Accumulation of oxidative damage is a common feature of neurodegeneration that, together
with mitochondrial dysfunction, point to the fact that reactive oxygen species are major …

Analogous to the term genomics, proteomics is defined as the analysis of the entire protein
complement expressed by a genome. However, proteomics is more diverse than genomics …

Neurodegenerative diseases cause memory loss and cognitive impairment. Results from
basic and clinical scientific research suggest a complex network of mechanisms involved in …

Aging is the major risk factor associated with neurodegenerative diseases, including
Alzheimer's disease (AD). Until now no clear understanding of the mechanisms of initiation …

Basal levels of oxidants are indispensible for redox signaling to produce adaptive cellular
responses such as vitagenes linked to cell survival; however, at higher levels, they are …

The brain is susceptible to oxidative stress, which is associated with age-related brain
dysfunction, because of its high content of peroxidizable unsaturated fatty acids, high …

Several studies demonstrated that oxidative damage is a characteristic feature of many
neurodegenerative diseases. The accumulation of oxidatively modified proteins may disrupt …

Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly
population with complex etiology. Many hypotheses have been proposed to explain different …

Increasing evidence supports the notion that increased oxidative stress is a fundamental
cause in the aging process and in neurodegenerative diseases. As a result, a decline in …