Local cerebral blood flow (CBF) responses to neuronal activity are essential for cognition
and impaired CBF responses occur in Alzheimer's disease (AD). In this study, regional CBF …

Objective: To investigate variation in the characteristics of regional cerebral blood flow
(rCBF), brain activity, and intrinsic functional connectivity (FC) across the Alzheimer's …

Alzheimer's disease (AD), the most common form of dementia, is characterized by neuronal
degeneration and cerebrovascular dysfunction. Increasing evidence indicates that …

Reductions of baseline cerebral blood flow (CBF) of∼ 10–20% are a common symptom of
Alzheimer's disease (AD) that appear early in disease progression and correlate with the …

Background Understanding the relationship between vascular disease and Alzheimer's
disease (AD) will enhance our insight into this disease and pave the way for novel …

Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

It has been suggested that cerebral blood flow (CBF) alterations may be involved in the
pathogenesis of Alzheimer's disease (AD). However, how CBF changes with age has not …

Impaired neurovascular coupling has been suggested as an early pathogenic factor in
Alzheimer's disease (AD), which could serve as an early biomarker of cerebral pathology …

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …

Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …