Alzheimer's disease (AD) is a devastating neurological degenerative disorder and is the
most common cause of dementia in the elderly. Clinically, AD manifests with memory and …

Amyloid β-protein (Aβ) may contribute to worsening of Alzheimer's disease (AD) through
vascular dysfunction, but the molecular mechanism involved is unknown. Using ex vivo …

Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …

Alterations in cerebral perfusion is increasingly considered to play a crucial role in
Alzheimer's disease (AD) and together with accumulated amyloid-β, deficiencies in the brain …

Alzheimer's disease (AD) is defined by senile plaques, tauopathy and neuronal cell death in
specific area of the brain. Recent studies suggest that neurovascular dysfunction may be an …

Cholinergic innervation in brain is involved in modulating neurovascular function including
cerebral blood flow hemodynamics in response to neuronal activity. Cholinergic deficit is …

Abstract Background The Blood–brain barrier (BBB) controls brain supply with oxygen and
nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Aβ) peptides …

Recently, aging societies have been showing an increasingly strong relationship between
Alzheimer's disease (AD) and chronic cerebral hypoperfusion (HP). In the present study, we …

Introduction Various lifestyle factors such as chronic hypertension and a high-sodium diet
regimen are shown to impact cerebrovascular morphology and structure. Unusual …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …