Cholinergic innervation in brain is involved in modulating neurovascular function including
cerebral blood flow hemodynamics in response to neuronal activity. Cholinergic deficit is …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Background Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central
event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology …

The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and protecting
neural tissue from damaging blood-borne agents. The barrier is characterized by endothelial …

Alzheimer's disease is associated with a 20–30% reduction in cerebral blood flow. In the
APP/PS1 mouse model of Alzheimer's disease, inhibiting neutrophil adhesion using an …

Objective: To establish the generality of cerebrovascular pathology frequently observed with
Alzheimer disease, we have assessed blood–brain barrier (BBB) integrity using the …

Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is
characterized by cerebral hypoperfusion, increased blood-brain barrier permeability and …

Early dysfunction of the blood-brain barrier (BBB) has been increasingly recognised as a
critical early event in Alzheimer's disease (AD) pathophysiology. Central to this mechanism …

Vascular dementia (VD) is defined as a progressive neurodegenerative disease of cognitive
decline, attributable to cerebrovascular factors. Numerous studies have demonstrated that …