The brain microcirculation is increasingly viewed as a potential target for disease-modifying
drugs in the treatment of Alzheimer's disease patients, reflecting a growing appreciation of …

Background Alzheimer's disease (AD) leads to a degeneration of the nucleus basalis of
Meynert and thus to decreased cholinergic tonus in the brain. The transcription of …

The Tg2576 transgenic mouse model of human cerebral amyloid angiopathy is
characterized by age-dependent cerebrovascular deposition of amyloid-β (A β) starting from …

Alzheimer's disease (AD) is a degenerative disorder characterized by a decreased regional
cerebral blood flow (CBF). It is most likely that a reduction in CBF could displace a pathway …

Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

In this study we tested the hypothesis that synapse loss contributes to decreased regional
cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and …

In this review we will examine the role of the autonomic nervous system in the control of
cerebral blood flow (CBF) in dementia. Worldwide, 55 million people currently live with …

INTRODUCTION Chronic cerebral hypoperfusion is one of the assumed pathophysiological
mechanisms underlying vascular cognitive impairment (VCI). We investigated the …

Based on enlarged blood oxygen level-dependent (BOLD) responses in cognitively normal
subjects at risk for Alzheimer's disease (AD), compensatory neuronal hyperactivation has …

Cerebrovascular hypoperfusion occurs prior to the clinical symptoms of Alzheimer's disease
(AD) and represents the most accurate indicator predicting whether an individual develops …