Regulation of cerebral blood flow (CBF) is critical for proper neural function. Therefore,
alterations in CBF regulation resulting from aging or age-related disease may have …

Although chronic cerebral hypoperfusion (CCH) may affect Alzheimer's disease (AD)
pathogenesis, the mechanism remains elusive. In the present study, we investigated the role …

Accounting for approximately 70% of dementia cases and rising globally, Alzheimer's
Disease Dementia (ADD) is a formidable challenge to patients, carers and healthcare …

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
accumulation of amyloid-beta (Aβ), hyperphosphorylation of tau, and neuroinflammation in …

Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

Increased incidence of stalled capillary blood flow caused by adhesion of leucocytes to the
brain microvascular endothelium leads to a 17% reduction of cerebral blood flow and …

Blood-brain barrier (BBB) dysfunction might be an important component of many
neurodegenerative disorders. In this study, we investigated its role in dementia using large …

Background Alzheimer's disease (AD) dementia is a consequence of heterogeneous and
complex interactions of age-related neurodegeneration and vascular-associated …

Background and Purpose Cognitive impairment resulting from cerebrovascular insufficiency
has been termed vascular cognitive impairment, and is generally accepted to be distinct …

Cardiovascular risk factors are associated with the development of Alzheimer's disease
(AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital …