Cerebrovascular dysfunction is a significant contributor to Alzheimer's disease (AD)
progression. AD mouse models show altered capillary morphology, density, and diminished …

Most patients with Alzheimer's disease exhibit accumulation of amyloid-β peptide on
leptomeningeal and cortical arterioles, or cerebral amyloid angiopathy, which is associated …

Cerebral microvasculature of patients with Alzheimer's disease (AD) exhibits reduced
capillary diameter and impaired blood flow. Molecular mechanisms of ischemic vessels …

Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting millions
of people worldwide. The classical hallmarks of AD include extracellular beta-amyloid (Aβ) …

Decreased blood flow to the brain in humans is associated with altered Alzheimer's disease
(AD)-related pathology, although the underlying mechanisms by which hypoperfusion …

Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid-beta (Aβ) on
the vascular wall, is a major pathology of Alzheimer's disease (AD) and has been thought to …

Fifteen Alzheimer (AD) and fifteen normative (NM) age-matched autopsy brains were
analyzed in superior temporal cortex, hippocampal and brainstem samples. Vascular …

Alzheimer's disease (AD) is an age-related disease, with loss of integrity of the blood–brain
barrier (BBB) being an early feature. Cellular senescence is one of the reported nine …

Apart from the cardiovascular system, several cerebrovascular defense mechanisms
inherently function to maintain homeostasis of the neurovascular unit. Prevailing evidence …

The neurovascular unit (NVU) plays an important role in maintaining the function of the
central nervous system (CNS). Emerging evidence has indicated that the NVU changes …