Cisplatin (CDDP) is a widely used drug for cancer treatment that exhibits major side effects
in normal tissues, such as nephrotoxicity in kidneys. The Nrf2 signaling pathway, a regulator …

Daphnetin, one of the major bioactive components isolated from Daphne odora, has been
reported to have anti-inflammatory and anti-oxidative effects. Inflammation and oxidative …

Danshen, an efficacious agent for cardiovascular diseases, has been found to play an
essential role in kidney injury. In the present study, the effect of Danshen on cisplatin …

In this study, the protective effects of pseudoginsengenin DQ (PDQ) on cisplatin (CDDP)-
induced nephrotoxicity were assessed, with a primary investigation into the mechanisms …

Gentamicin (GM), an aminoglycoside antibiotic, is one of the most effective drugs used in the
treatment of various types of bacterial infections, but the major adverse effect and drug …

Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for
chemotherapy, is common. To date, there is an urgent need to find effective treatments to …

Cisplatin is a chemotherapy drug that is often used in clinical practice, but its frequent use
often leads to nephrotoxicity. Therefore, we urgently need a drug that reduces the …

The clinical application of cisplatin was mainly limited by severe nephrotoxicity. Danshensu
was the main pharmacological active diterpenoids which extracted from the roots of Salvia …

Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is
governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways …

Cisplatin‐(CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin.
Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin …