Programmed cell death 1 (PD-1) and its ligands PD-L1 and PD-L2 are receptors that act in
co-stimulatory and coinhibitory immune responses. Signaling the PD-1/PD-L1 or PD-L2 …

To cite this article: Singh AK, Stock P, Akbari O. Role of PD‐L1 and PD‐L2 in allergic
diseases and asthma. Allergy 2011; 66: 155–162. Abstract Asthma is the result of chronic …

Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to
mediate the mechanism of immune tolerance and provide immune homeostasis …

The regulation of T cell response depends on co-inhibitory pathways that serve to control
immune-mediated tissue damage and resolve inflammation by modulating the magnitude …

Abstract The PD-1/PD-L1 axis is a complex signaling pathway that has an important role in
the immune system cells. Programmed cell death protein 1 (PD-1) acts as an immune …

T-cell activation is dependent on signals delivered through the antigen-specific T-cell
receptor and accessory receptors on T-cells. Integration of signals through this family of …

Abstract Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers
negative signals upon interaction with its two ligands, PD-L1 or PD-L2. PD-1 and its ligands …

Summary Background Targeting PD‐1/PD‐1 ligand signalling is an established treatment
option for cancer. The role of these molecules in allergic asthma has been investigated in …

Cancer immunotherapy has been accompanied by promising results over the past few
years. Programmed Cell Death Protein 1 (PD-1) plays a vital role in inhibiting immune …

Immune evasion is a key strategy adopted by tumor cells to escape the immune system
while promoting their survival and metastatic spreading. Indeed, several mechanisms have …