Background The use of alpha-2 adrenergic agonists for analgesia is limited due to a narrow
therapeutic window. Definition of the role of alpha receptor subtypes in alpha agonist …

Background Studies on receptor knockout mice have so far shown that of the three alpha2-
adrenoceptor subtypes, the alpha (2A) adrenoceptor has a major role in mediating the …

Background Previous studies suggest that the alpha adrenoceptor subtype is the target for
spinally administered alpha-adrenergic agonists, clonidine, for pain relief. However, ST 91 …

The a,-adrenoceptor agonists may become an attractive alternative to the currently used
analgesics because they are devoid of respiratory depressant effect and addictive liability …

Publisher Summary The antinociceptive actions of α 2-adrenergic receptors (α 2 ARs)
agonists are exerted via α 2A ARs. These represents, thus, an attractive development target …

The α-2 adrenergic receptor agonists have been used for decades to treat common medical
conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and …

Clonidine is a partial alpha 2 adrenergic agonist that has a variety of different actions
including antihypertensive effects as well as the ability to potentiate the effects of local …

THE Adrenergic system, because of its reported implica-tion in pain mechanisms, may be a
potential target for chronic pain treatment. A genetic polymorphism of catechol-O …

IMPLICATIONS: Localized peripheral administration of analgesics is one alternative for pain
control. We investigated the role of adrenergic receptor subtypes on peripheral transmission …

The multiple clinical actions of clonidine have historically been linked to the same receptor
(α 2-adrenoceptor) due to the belief that clonidine was a selective α 2-agonist. However, it is …